Tag: Medicine

Computational Insight into Molecular Mechanism of Differentiated Allosteric Modulations at the Mu Opioid Receptor by Structurally Similar Opioid Ligands
9th Dec 2019
Introduction: Computational insight into molecular mechanism of differentiated allosteric modulations at the mu opioid receptor by structurally similar opioid ligands ABSTRACT: Activating or blocking the mu opioi...

Computational Cardiology: Trends and Needs
9th Dec 2019
Introduction: Abstract— Computational cardiology is the scientific field devoted to the development of methodologies that enhance our mechanistic understanding, diagnosis and treatment of cardiovascular disease...

Fibroblast Replication and Matrix Deposition for Pulmonary Fibrosis
9th Dec 2019
Introduction: Introduction Introduction to Pulmonary Fibrosis Pulmonary Fibrosis (PF) describes a dissimilar group of lung disorders characterized by progressive and irreversible destruction of lung architecture g...

Disorder Case Study: Acute Viral Gastroenteritis
9th Dec 2019
Introduction: Introduction Acute gastroenteritis, commonly known as infectious diarrhoea, is the inflammation of the gastrointestinal tract, which can result in vomiting, abdominal pain and persistent diarrhoea. ...

Metabolic Analysis of Tumours
9th Dec 2019
Introduction: Enrichment of Genomics with Clinically Informative Molecular Phenotyping (Personalized OncoMetabolomics) Abstract Cancer is one of the most devastating human diseases, and it causes an enormous numb...

Prostate-specific Membrane Antigen for Prostate Cancer
9th Dec 2019
Introduction: Abstract Prostate cancer (PC) is the most common type of cancer and the second cause of death in men in the UK. It has been primarily treated with radiotherapy and hormonal therapy but this approach ...

Mechanics of Diseased Red Blood Cells in Human Spleen and Consequences for Hereditary Blood Disorders
9th Dec 2019
Introduction: In red blood cell (RBC) diseases, the spleen contributes to anemia by clearing the damaged RBCs, but its unique ability to mechanically challenge RBCs also poses the risk of inducing other pathogenic...

Ubiquitin Proteasome System Role in the Immune System and Therapeutic Potential of Targeting Specific Pathway Components
9th Dec 2019
Introduction: Introduction- In order to maintain cellular homeostasis, a continual cycle of protein production and degradation is required. Protein level in cells is maintained through “proteostasis” which ref...

Optical Coherence Tomography Angiography
9th Dec 2019
Introduction: Optical coherence tomography angiography  Background The development of angiographies has been a long time in the making with initial progress dating back to the discovery of the circulation of bloo...

Osteogenesis Imperfecta: Differentiating Clinical Presentation from Non-Accidental Injury
9th Dec 2019
Introduction:  ABSTRACT: This paper will focus on differentiating the pathologic fractures of osteogenesis imperfecta (OI), a bone fragility disorder that manifests in childhood, from the fractures typically susta...

Allergic Rhinitis: Epidemiology, Pathophysiology and Immunology
9th Dec 2019
Introduction: Chapter 1 INTRODUCTION                    Allergy Allergy is an IgE (Immunoglobulin E) mediated type I hypersensitivity disorder involving an abnormal reaction to an ordinarily ha...

Drug Encapsulation on Phosphoglycerolipids
9th Dec 2019
Introduction: Abstract: Although Cancer is the major cause of death in many countries around the world, the efficacy of current standard treatments is suboptimal. The main drawbacks of conventional chemotherapy ar...

Cancer Cell Lines Cultured and Irradiated With a 2Gy X-ray Radiation
9th Dec 2019
Introduction: What is radiation Radiation is the emission of energy in the form of rays or waves and is classified into two categories; ionizing and non-ionizing. This classification is dependent on the amount of ...

Development and Student Evaluation of an Interactive 3-dimensional Skin Lesion Model for First Year Medical Student Education
9th Dec 2019
Introduction: Title: Dermatology Tactile Learning Tool: Development and student evaluation of an interactive 3-dimensional skin lesion model for first year medical student education Keywords: dermatology; education...

Evolution of Infectious Disease: Creuztfeldt-Jakob Disease
9th Dec 2019
Introduction: Life History: Prion dieases (PrD), are fatal neurodegenerative diseases found in humans and different animal species. Prions are the infectious agents of these diseases and consist of large protein ag...

Thalidomide Disaster: Have Medical and Pharmaceutical Industries Learnt past Mistakes?
9th Dec 2019
Introduction: Following the thalidomide disaster: Have the Medical and Pharmaceutical industries learnt from factors that contributed to past mistakes? Abstract A report exploring and evaluating how the pharmace...

Simulation for acute gynaecological emergencies - a training needs analysis
9th Dec 2019
Introduction: Introduction Simulation in teaching doctors remains and has been recognized to be an important contributary factor to a doctor’s development, towards becoming or transitioning into a better clini...

Breast Cancer, Family History and Genetic Testing; What Are the Barriers to Genetic Testing?
9th Dec 2019
Introduction: Contents Page Abstract                4 Introduction                          5-7 Methodology                         8-9 Results   ...

Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina
9th Dec 2019
Introduction: Investigating the effects of dietary nitrate on vascular function, platelet reactivity and restenosis in stable angina (NITRATE-OCT) ABSTRACT Background Primary coronary intervention (PCI) is common...

Analytics on Risk Factors related to Non-communicable Diseases
9th Dec 2019
Introduction: ABSTRACT Non-Communicable diseases (NCDs) is a major global problem which includes diseases like cancer, heart diseases which will report to death. The healthy lifestyle habits should be maintained t...

The Age-Associated Deterioration in Muscle Performance
9th Dec 2019
Introduction: The Age-Associated Deterioration in Muscle Performance Introduction The population of Canada is continually growing older with 16.9% of the population being 65 years and older in 2016 (“The Dai...

Clinical insights about Topical Treatment of Mild-To-Moderate Atopic Dermatitis in children and Adults – Consensus
9th Dec 2019
Introduction: Abstract Atopic dermatitis (AD), also known as atopic eczema, is a chronic inflammatory skin disease that is characterised by intense itching and recurrent eczematous lesions. It predominantly starts...

Management of Medullary Thyroid Cancer: Pre-operative Calcitonin to Guide the Extent of Surgery
9th Dec 2019
Introduction: TITLE: Review of the Management of Medullary Thyroid Cancer in New Zealand: pre-operative calcitonin to guide the extent of surgery INTRODUCTION Medullary thyroid carcinoma (MTC) originates from paraf...

Rac1-mediated Pathways Using Small Molecule Inhibitors for Cancer Treatment
9th Dec 2019
Introduction: Cellular Metabolism: Normal: In order to function optimally and maintain homeostasis, mammalian cells utilize glucose as the main source of energy. Given that glucose is the most abundant nutrient fo...

Improving Pancreas Graft Utilization Through Importation
9th Dec 2019
Introduction: Improving Pancreas Graft Utilization Through Importation Running Head: Utilization of Imported Pancreata Abstract Background Here we investigate whether using imported pancreata is a feasible strateg...