Mitochondrial DNA m.3243A>G Heteroplasmy Affects Multiple Aging Phenotypes and Risk of Mortality
16th Dec 2019
Introduction:
Mitochondrial DNA m.3243A>G heteroplasmy affects multiple aging phenotypes and risk of mortality
Abstract
Mitochondria contain many copies of a circular DNA molecule (mtDNA), which has been observ...
Tag: Genomics
Browse all dissertation content tagged as "Genomics" including dissertation examples, dissertation proposals, topic and title ideas, individual dissertation chapter examples, and help guides for both undergraduate and masters students.
Articles
The Roles of ∆Np63 in EMT
16th Dec 2019
Introduction:
Chapter 1: Introduction
1.1 p63, a member of p53 protein family
1.1.1 An overview
The discovery and cloning of TP63 gene, a homolog of the tumor suppressor TP53, in 1998 has bro...
ASE Using DNA-seq and RNA-seq Data
16th Dec 2019
Introduction:
ASE using DNA-seq and RNA-seq data
Introduction
One of the major steps in determining ASE requires identification of heterozygous biallelic variant sites. From a NGS perspective, when reads gene...
Inclusion of Whole-Genome Sequencing with Parental Consent
16th Dec 2019
Introduction:
Inclusion of Whole-Genome Sequencing with Parental Consent
With the advent of the public health program of Newborn screenings, many metabolic deficiencies such as phenylketonuria (PKU) were caught be...
Gene Expression Profile of the Hippocampus of Rats Subjected to Diffuse Axonal Injury
16th Dec 2019
Introduction:
Gene Expression Profile of the Hippocampus of Rats Subjected to Diffuse Axonal Injury
Abstract:
Background: The patient usually appears some serious complications and the nerve function obstacle a...
Investigation of the Roles of ASF1 and CAF-1-mediated Chromatin Assembly in the Human DNA Damage Response
16th Dec 2019
Introduction:
INVESTIGATION OF THE ROLES OF ASF1 AND CAF-1-MEDIATED CHROMATIN ASSEMBLY IN THE HUMAN DNA DAMAGE RESPONSE
The access-repair-restore model for the role of chromatin in DNA repair infers that chromati...
Plant Design and Manufacturing Principles in DNA Vaccine Production
13th Dec 2019
Introduction:
Abstract
The demand for DNA vaccines in large quantities at high purity for gene therapy is on the increase. As it helps to stimulate antibodies production in human and provide immune protection agai...
Photostability of DNA
13th Dec 2019
Introduction:
Abstract
Ultra-Violet
(UV) radiation may result in skin cancer due to the hypothesis that DNA
photostability provides a small allowance for photoreactions. DNA has been
protected by the Ozone laye...
Genetic Factors for Anorexia Nervosa
13th Dec 2019
Introduction:
Abstract
Introduction & Background: Anorexia Nervosa (AN) is a chronic psychiatric eating disorder characterised by restricted eating, a relentless pursuit of weight loss and having a distorte...
Treating Cystic Fibrosis with Gene Therapy
12th Dec 2019
Introduction: In this dissertation we shall consider the field of gene therapy in specific relation to cystic fibrosis.
We examine the different delivery vector mechanisms that have already been explored and conc...
Advances in DNA Sequencing Technologies
12th Dec 2019
Introduction: Abstract
Recent advances in DNA sequencing technologies have led to efficient methods for determining the sequence of DNA. DNA sequencing was born in 1977 when Sanger et al proposed the chain terminat...
Genetic Polymorphism Governing the CYP2D6 Cytrochrome
11th Dec 2019
Introduction: Genetic Polymorphism Governing the CYP2D6 Cytrochrome P450 Enzyme Subfamily in Drug Metabolism
I. Abstract
The decoding of the human genome has opened up an immense opportunity for further research i...
Human Genome Project: Legal, Ethical and Social Implications
11th Dec 2019
Introduction: In this dissertation we consider the human genome project in its wider context. We take a brief overview of the aims, the working and the sequencing techniques used together with the timeline achieved...
Haemoglobin-related Diseases Management Strategies
11th Dec 2019
Introduction: Abstract
Haemoglobinopathies or inherited disorders of haemoglobin are the most common monogenic disorders in humans. Red cell transfusion is a well accepted therapy for clinical management of the mos...
Genetically Controlled Overexpression of Genes in the Early Drosophila Embryo
11th Dec 2019
Introduction:
Abstract
The specific functions of gene products frequently depend on the developmental context in which they are expressed. Thus, studies on gene function will benefit from systems that allow for ma...
Charcot-Marie-Tooth Disease (CMT) Genomics
11th Dec 2019
Introduction:
Charcot-Marie-Tooth disease (CMT) is a clinically distinct autosomal dominant disease caused by a 1.5 Mb tandem duplication on chromosome 17. Only recently with the help of molecular genetic studies ...
CDEs as Gene and Oligonucleotide Carriers
11th Dec 2019
Introduction:
Introduction
The principle of somatic gene therapy is to introduce certain genes into selected cells to treat a genetic or acquired disease by interfering with the expression of specific proteins o...
How Is Genetic Engineering Altering the Process of Natural Evolution and to What Extent Is It Beneficial and Ethically Acceptable?
10th Dec 2019
Introduction:
How is genetic engineering altering the process of natural evolution and to what extent is it beneficial and ethically acceptable?
Abstract
This project will focus on how natural evolution...
Assessment of Parametric and Resampling Methods for Prediction of Quantities Traits
10th Dec 2019
Introduction:
Assessment of parametric and resampling methods for prediction of quantities traits with non-additive genetic architecture
Abstract
Whole genome evaluation of quantitative traits using suitable stati...
Characterization of natural selection on gene duplicates
10th Dec 2019
Introduction:
Specific Aims
Gene duplication is an important source of evolutionary novelty. Various mechanisms were proposed to explain how duplicates could be retained in the genome, and there exist numerous emp...
Technological Advances in DNA Analysis
10th Dec 2019
Introduction:
PROBLEM STATEMENT
This research focuses on the technological advancements in DNA Analysis over the past years. There has been many changes made in the process of DNA Analysis, but with the changes, w...
Genetic Impacts on Child Development and Supporting Special Needs
9th Dec 2019
Introduction:
Context
Factors affecting child development from both hereditary and genetic causes
A child’s overall developmental needs
Special needs defined
Supporting a child with special needs
Key transition...
Genetic Etiology of Parkinson's Disease
9th Dec 2019
Introduction:
Abstract
Parkinson disease (PD) is known as a common progressive neurodegenerative disease which is clinically diagnosed by the manifestation of numerous motor and nonmotor symptoms. PD is a geneti...